The impact of tumour pH on cancer progression: strategies for clinical intervention

The impact of tumour pH on cancer progression: strategies for clinical intervention

Blog Article

Dysregulation of cellular pH is frequent in solid tumours and provides Hookah Tongs potential opportunities for therapeutic intervention.The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms.Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters Swivel Desk Chair (MCT, MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump, and the sodium-hydrogen exchanger 1.

This review will describe progress in the development of inhibitors to these targets.